Modeling Signaling Processes across Cellular Membranes Using a Mesoscopic Approach

Computational models are effective in providing quantitative predictions on processes across cellular membranes, thereby aiding experimental observations. Conventional computational tools, such as molecular dynamics or Monte Carlo simulation, offer significant insights when applicable. However, it remains extremely difficult to use these simulation methods to describe large 1 Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY, USA 2 Institute of Chemistry and the Fritz Haber Research Center, The Hebrew University of Jerusalem, Jerusalem, Israel Annual Reports in Computational Chemistry, Volume 6 2010 Elsevier B.V. ISSN: 1574-1400, DOI 10.1016/S1574-1400(10)06012-3 All rights reserved.